Sometimes a placebo is not a placebo

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Placebos are used in clinical trials to demonstrate that an experimental drug is superior to the control or “inactive” pill (1). A placebo is usually defined as an “inert substance” (no effect), given to trial participants with the aim of making it impossible for them, and usually the researchers themselves, to know who is receiving an active or inactive therapy. The exact contents of a placebo pill are often unknown; the “recipe” is not disclosed to the trial subjects, nor is it published in the peer-reviewed literature. Recently, the editor-in-chief of Clinical Therapeutics, Dr. Robert Shader, raised concerns when a …read more

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