Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature

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Circadian rhythms are moderated by two “clocks.” The first clock is a “master clock” that responds to daily dark-light cycles, is regulated in the hypothalamus, and regulates various circadian processes in the rest of the body via neuronal and hormonal signals (1). The second clock responds to meal times, and in particular to regular patterns of feeding and fasting (2). This second clock can override the impact of the master clock on organs and tissues if mealtimes and the duration between meals are deliberately manipulated (3). Disruptions to circadian rhythm have been linked to impaired glucose and lipid metabolism, cancer, …read more

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