Systemic sclerosis or SSc is a disease that causes fibrosis and vascular disorder along with autoimmune changes. This disease involves fibroblast activity that causes abnormal growth of the connective tissues. SSc gives birth to a number of skin problems including ulcers, itchy skin, and many other complexities. It is difficult to conclude what actually causes systemic sclerosis. It can be considered as a multisystem disease of an unknown cause. The term “autoimmune” (mentioned above) implies that the immune system is responding against the associated tissues. Pathogenesis brings both activated B cells and activated T lymphocytes together. As an outcome, autoantibodies …read more
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